Emails not sending

Having an issue with 2 of our email addresses not sending email. We are mostly having this issue when using Outlook, but also now having a problem sending a forward email using Roundcube. I am receiving the following error messages. 

A message that you sent could not be delivered to one or more of its
recipients. This is a permanent error. The following address(es) failed:

  brent@delkperformance.com
    host eig-east.smtp.a.cloudfilter.net [18.215.58.191]
    SMTP error from remote mail server after end of data:
    550 Q5zpv3HzEw44vQ5zpvknAT - <general@delkperformance.com> message rejected AUP#SNDR

Technical details

SmtpSubmissionPermanent5XXException: Smtp submission failed. Server 'smtp.homestead.com' Port '465'. --> Unexpected SMTP server response. Expected: 250, actual: 550, whole response: 550 Q4GGvoXqSh8QWQ4GHvUHRu - <general@delkperformance.com> message rejected AUP#SNDRFailure code: 1988Technical details

SmtpSubmissionPermanent5XXException: Smtp submission failed. Server 'smtp.homestead.com' Port '465'. --> Unexpected SMTP server response. Expected: 250, actual: 550, whole response: 550 Q5TCvBLVMHSQMQ5TDvIdmT - <general@delkperformance.com> message rejected AUP#SNDRFailure code: a122I am also receiving another failure code, but I cannot find it at the moment.